Muscle Building

Like methandrostenolone (Dianabol)
oxymetholone does not bind well to the androgen receptor (AR)
and most of the anabolism it provides is via non-AR-mediated effects. It is therefore a Class II steroid and is best stacked with a Class I steroid. The drug appears to give the same benefits as dianabol. Unlike Dianabol
however
it seems that oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens
strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of stanozolol (Winstrol)
which is anti-progestagenic. This
progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan
oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast
with testosterone it is a very harsh drug.

Oxymetholone does not convert to estrogen
and thus antiestrogens are not required if no aromatizable AAS are being used. However
in concert with aromatizing drugs
oxymetholone is notorious for worsening "estrogenic" symptoms
possibly by producing progestagenic symptoms which the bodybuilder
confuses as estrogenic
or by altering estrogen metabolism
or by upregulating aromatase.

Compared to what bodybuilders expect of it
the drug is reasonably mild when no aromatizing steroids are present. I consider its potency approximately comparable to Dianabol. It is not unusual for a first time user to do quite well on an oxymetholone-only cycle
but more advanced users will want
to stack with another steroid. Typical use is 50-150 mg/day
which should be divided into several doses per day.

Because oxymetholone is 17-alkylated
it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle
rather than in the last few weeks.


Trivial name Oxymetholone
Systematic name 5-alpha
17
17
number 434-07-1
ATC code A14AA05
Merck Index Number 7036
Chemical formula C21H32O3
Molecular weight 332.477 g/mol
Bioavailability 95%
Metabolism Hepatic
Elimination half-life 9 hours
Excretion Urinary: 95%
Pregnancy category X
Routes of administration Oral